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PDEs as drug targets

Phosphodiesterases make good drug targets because they bind small ligands and share similar catalytic mechanisms, while displaying unique architectures around their active sites. This allows for the development of selective inhibitors.
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PDE4NPD and the EU

The PDE4NPD Project is one of four neglected parasitic disease (NPD) projects funded under the auspices of the European Commission’s FP7 HEALTH programme.
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Latest news

PDE4NPD at EFMC International Symposium on Medicinal Chemistry

Several members of the PDE4NPD consortium will be presenting at the XXIV EFMC International Symposium on Medicinal Chemistry, in Manchester, UK, from August 28 - September 1. Would you like to learn more about the PDE4NPD project? Visit our posters!

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Sleeping sickness

Puts 65 million people at risk of infection, with 20,000 new cases annually. Affects the central nervous system, and also inflicts economic damage via infections in cattle.

Leishmaniasis

A parasitic sporadic/epidemic disease infecting more than 12 million people worldwide, causing 20-30,000 deaths each year.

Chagas Disease

Causes cardiac disorders or digestive alterations in 40% of patients, and can lead to death (7,000 each year) or life-long disability. Chronically infects 6-7 million people.

Schistosomiasis

Affects 78 countries, with 240 million infected people – imposing an economic burden second only to malaria in endemic countries.